Asthma Treatment in Manipal Hospital Whitefield :
Asthma is the most frequent chronic inflammatory airway disease globally with a prevalence reaching 5–10% [1], affecting 339 million people worldwide [2]. Asthma is defined by the cardinal symptoms of breathlessness, wheeze, chest tightness and cough, together with the presence of exaggerated expiratory airflow fluctuation that varies over time.
Its recommended performing spirometry to detect airway obstruction as part of the diagnostic work-up of adults aged 18 years with suspected asthma
An FEV1/FVC <LLN or <75% should be considered supportive of an asthma diagnosis and should prompt further testing
A normal spirometry does not exclude asthma
In patients suspected of asthma, in whom the diagnosis is not established based on the initial spirometry combined with bronchodilator reversibility testing, the TF suggests measuring the fraction of exhaled nitric oxide (FeNO) as part of the diagnostic work-up of adults aged >18 years with suspected asthma
What makes an individual foster asthma?
Asthma affects people in different ways. There may be a number of reasons for this, including a person’s genetic makeup, lifestyle factors which can affect asthma are Psychological conditions, such as anxiety, stress or depression, and Environmental factors, such as living in an area with high levels of air pollution, living in a building with dampness or mould or being exposed to second-hand smoke. Occupational factors, such as working with dust, baker’s flour, chemicals or other triggers of asthma in the workplace. Treatment must therefore be tailored to each individual.
You may have another condition that you need to manage alongside your asthma.
Some co-morbidities can affect asthma control, like Acid reflux, Nasal polyps, Obesity, and Obstructive sleep apnoea.
Asthma is a heterogeneous disease that encompasses different clinical phenotypes and endotypes that share excessive airflow fluctuation . In particular, there is now clear evidence of differing patterns of airways inflammation in people with asthma.
What are allergens?
Allergens are minuscule protein substances that are normal and incite hypersensitive individuals to create cures (antibodies).
The most well-known sensitivity inciting substances are:
- House dust mites
- Pollen from weeds, grass, flowers and trees
- Mould and mould fungus
- Fur from cats and dogs
- Medicines
Precision medicine in Asthma
A landmark advance in the treatment of severe asthma is the availability of a handful of powerful biologics that block different branches of the T2 response and have been convincingly shown to improve asthma control and prevent exacerbations in patients with severe disease. It is now clear that the availability of these new medicines has changed the treatment landscape.
In asthma biologics are referred to monoclonal antibodies which binds to a specific determinant, for example, a cytokine or receptor. Owing to this selectivity, biologics are ideal for “personalized” or “precision” medicine.
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